Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy

Recruiting now · Not applicable

Conditions studied: Mastectomy; Lymphedema, Chronic Pain, Regional Anesthesia Morbidity, Opioid Use

In brief

The goal of this clinical trial is to learn if the erector spinae block can reduce the incidence of chronic pain compared to the paravertebral block in adult patients undergoing total mastectomy. The study includes patients aged 18 to 80 years scheduled for mastectomy, with or without axillary dissection. The main questions it aims to answer are: * Does erector spinae block reduce the incidence of chronic pain at 3 months after mastectomy compared to paravertebral block? * Does erector spinae block affect postoperative outcomes such as opioid consumption at 48 hours, pain scores (in PACU, 24 and 48 hours), block performance time, and the incidence of complications, anxiety or depression, and pain intensity at 3 months? Researchers will compare patients receiving erector spinae block to those receiving paravertebral block to determine if erector spinae block provides equivalent or improved outcomes in terms of chronic pain and perioperative measures. Participants will: * Be randomly assigned to receive either erector spinae block or paravertebral block prior to surgery * Undergo total mastectomy (with or without axillary dissection) * Have their pain assessed in the PACU and at 24 and 48 hours postoperatively * Have opioid consumption measured during the first 48 hours after surgery * Be followed up at 3 months to assess chronic pain, pain intensity, and psychological outcomes (anxiety or depression)

Key facts

Study ID

NCT07561411

Run by

American University of Beirut Medical Center

People needed

132

Starts

2026-05-19

Expected to finish

2028-05-01

Last updated by the study team

2026-06-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult patients between 18 and 80 years old.
• Scheduled to total mastectomy with or without axillary dissection
• Willing to receive regional anesthesia in addition to GA
• ASA classification 1-3

You may not qualify if…

• Previous thoracic surgery with an incision of >2 cm
• Patient's refusal
• Allergy to local anesthetics
• Pregnant women
• Any contraindications to thoracic PVB, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy; anticoagulants intake.
• American Society of Anesthesiologists (ASA) classification of 4 or higher,
• History of chronic pain or untreated clinical severe depression

Where it is running

• American University of Beirut Medical Center — Beirut, Lebanon (enrolling)

Full record on ClinicalTrials.gov

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