Multidimensional Omics Analysis in Malignant Pleural Mesothelioma
Recruiting now
Conditions studied: Malignant Pleural Mesothelioma (MPM)
In brief
Malignant pleural mesothelioma (MPM) is a rare and incurable cancer. Most patients are diagnosed with unresectable disease for which treatment options are limited. The lack of prognostic biomarkers further complicates the decision-making. Recently, the introduction of immune checkpoint inhibitors (ICIs) has marked a shift but has failed to produce significant benefits for a large proportion of patients. Maximizing the efficiency of ICIs and developing new protocols to improve drug efficacy is the best possible strategy for improving the life expectancy and quality of life of patients with MPM. This study aims to characterize the organization of the immune system infiltrating mesothelioma and the dynamics of its interaction with the tumor. The rationale is that deciphering this complexity will help improve our understanding of the mechanisms underlying this disease and provide a new tool to optimize the use of ICIs in these patients.
Key facts
- Study ID
- NCT07561190
- Run by
- Azienda USL Reggio Emilia - IRCCS
- People needed
- 300
- Starts
- 2024-08-30
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participant is willing and able to give informed consent for participation in the study
- Aged > 18 years
- Patients with histologically confirmed diagnosis of MPM
- Availability of biological material
- Clinical indicatio of eligibility for HITOCH protocol (only for C3 cohort)
You may not qualify if…
- Active current infection
- Autoimmune disease
- Women in childbearing age not able to exclude pregnancy
Where it is running
- Azienda Ospedaliera Universitaria Policlinico Rodolico San Marco di Catania — Catania, Italy (enrolling)
- Azienda Ospedaliera Universitaria Luigi Vanvitelli, Napoli — Naples, Italy (enrolling)
- Azienda USL IRCCS di Reggio Emilia — Reggio Emilia, Italy (enrolling)
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Roma, Italy (enrolling)
Full record on ClinicalTrials.gov
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