Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

Starting soon

Conditions studied: Multiple Sclerosis, Internuclear Ophthalmoplegia

In brief

Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS. The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion. The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.

Key facts

Study ID

NCT07560995

Run by

University Hospital, Strasbourg, France

People needed

200

Starts

2026-05-01

Expected to finish

2027-05-01

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis
• Patients hospitalized in a neurology department

You may not qualify if…

• Patients under 18 years of age

Where it is running

• Les Hôpitaux Universitaires — Strasbourg, France

Full record on ClinicalTrials.gov

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