Evaluating Adherence to Guideline-Directed Medical Therapy in Patients With Advanced Heart Failure
Recruiting now
Conditions studied: Heart Failure
In brief
A Prospective Observational, Multi-Center, Real-World Pharmacological Study Evaluating Adherence to Guideline-Directed Medical Therapy Using the Four-Pillar Strategy in Patients with Advanced Heart Failure
Key facts
- Study ID
- NCT07560982
- Run by
- Università Vita-Salute San Raffaele
- People needed
- 300
- Starts
- 2026-05-08
- Expected to finish
- 2036-07-01
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 and < 75 years
- Heart failure with left ventricular ejection fraction ≤ 35%
- Persistent symptoms of heart failure, New York Heart Association class III or IV
- Requirement for high-dose diuretic therapy, specifically Furosemide > 50 mg/day orally as per routine clinical practice
- At least one of the following additional indicators of severity or refractoriness:
- need for progressive escalation of diuretics,
- intolerance to optimized medical therapy,
- persistence of symptoms despite advanced treatments such as (but not limited to) cardiac resynchronization therapy (CRT-D)and/or MitraClip
- Ability and willingness to provide written informed consent for participation and for the processing of clinical data for research purposes
You may not qualify if…
- Age ≤ 18 years or ≥ 75 years
- Left ventricular ejection fraction > 35%
- Mild or absent symptoms (New York Heart Association class I-II)
- Good response to optimized conventional guideline-directed medical therapy
- Extreme frailty or severe non-reversible disability, or psychiatric or cognitive disorders preventing adherence to follow-up
- Pregnant or breastfeeding women
Where it is running
- IRCCS Ospedale San Raffaele — Milan, Italy (enrolling)
- ASST Ospedale Papa Giovanni XXIII — Bergamo, Italy
Full record on ClinicalTrials.gov
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