Nutritional Intervention Implication in Enhanced Recovery After Surgery for Whipple Procedure

Recruiting now · Not applicable

Conditions studied: Pancreatic Cancer, Ampulla of Vater Adenocarcinoma, Billiary Track Cancer

In brief

The objective of this research is to assess the impact of personalized nutritional intervention on postoperative complications and length of stay in Whipple's patients via assessing the parameters related to body composition, nutritional status, weight maintenance, biochemical profile (LFTs, RFTs, CBC, CRP, serum electrolytes, coagulation profile and HbA1c) and muscle preservation postoperatively. Moreover, enhanced recovery after surgery (ERAS) guidelines in Whipple's patients will also be monitored. Exactly 20 patients undergoing Whipple's Procedure/PPPD in 1 year will be recruited for the study. Medical nutrition therapy will include energy intake of 25- 30 Kcal/kg body weight and protein 1.2-1.5g/kg body weight. Enteral nutrition and parenteral nutrition will be given accordingly. After discharge, patients receiving chemotherapy and patients not receiving chemotherapy will be nutritionally intervened accordingly. Follow-ups will be done in the 2nd week, 3rd month and 6th month after surgery. Data will be analyzed using SPSS version 27. To assess the significant difference among study groups t-test, repeated measure analysis of variance (ANOVA) and regression model will be applied. The level of significance will be kept at 5%. t-test for treatment groups.

Key facts

Study ID

NCT07560540

Run by

University of Veterinary and Animal Sciences, Lahore - Pakistan

People needed

20

Starts

2025-12-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Malignancy of;
• Distal common bile duct
• Pancreatic head
• Periampullary
• Duodenal
• Patients scheduled for elective Whipple's procedure (laparoscopic and open)
• Age 18 and above

You may not qualify if…

• Patients undergoing Whipple's procedure for reasons other than malignancy
• Patients undergoing emergency procedures
• Patients with significant preoperative complications prohibiting oral intake
• Age below 18

Where it is running

• Shalamar Hospital — Lahore, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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