Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma:

Recruiting now · Phase 3

Conditions studied: Nasopharangeal Cancer

In brief

This study investigated the effects of topical chlorhexidine spray on the incidence, severity, and quality of life during radiotherapy in nasopharyngeal carcinoma patients.

Key facts

Study ID

NCT07559877

Run by

Jiangxi Provincial Cancer Hospital

People needed

148

Starts

2026-04-01

Expected to finish

2027-09-30

Last updated by the study team

2026-04-30

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed nasopharyngeal carcinoma. Clinical stage II-III disease with N≥1, according to the UICC/AJCC 9th edition. Planned to receive first-course definitive chemoradiotherapy, with a total radiotherapy dose of 60-70 Gy.
• Able to communicate and complete study assessments. Willing to participate and able to provide written informed consent. Eligible based on baseline assessments performed before chemoradiotherapy.

You may not qualify if…

• History of or current psychiatric disorder, cognitive impairment, or other severe organic disease.
• Presence of another concomitant malignancy. Receipt of any other prophylactic intervention for radiation dermatitis. Pre-existing skin disease before chemoradiotherapy. Known hypersensitivity or allergy to chlorhexidine.

Where it is running

• Jiangxi Cancer Hospital — Nanchang, Jiangxi, China (enrolling)

Full record on ClinicalTrials.gov

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