Multi-target TMS for Schizophrenia Negative Symptoms
Recruiting now · Not applicable
Conditions studied: SCHIZOPHRENIA 1 (Disorder)
In brief
This randomized controlled trial (RCT) is the first to evaluate the efficacy and safety of a multi-target TMS protocol targeting the left dorsolateral prefrontal cortex (L-DLPFC), left inferior parietal lobule (L-IPL), and right orbitofrontal cortex (R-OFC) for negative symptoms of schizophrenia.
Key facts
- Study ID
- NCT07559084
- Run by
- Shanghai Mental Health Center
- People needed
- 64
- Starts
- 2026-05-01
- Expected to finish
- 2028-01-30
- Last updated by the study team
- 2026-04-30
Who can join
Age: 16 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Outpatients or inpatients at the Department of Psychiatry, Shanghai Mental Health Center;
- Meet the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for first-episode schizophrenia (diagnosed using the Structured Clinical Interview for DSM-5, SCID-5); disease duration less than 5 years at enrollment;
- Male or female aged 16-45 years;
- Education duration ≥ 9 years;
- Stable medication regimen for at least 6 weeks prior to baseline visit and throughout the study period; psychiatric symptoms generally stable within 1 month prior to baseline visit;
- Participants and their guardians can understand and sign written informed consent;
- Total score on the PANSS Negative Symptom subscale (PANSS-N) > 15, and at least one item score ≥ 3.
You may not qualify if…
- Current or lifetime psychiatric disorders as determined by SCID-5 assessment;
- Severe or unstable physical illnesses, including: neurological disorders (delirium, dementia, stroke, epilepsy, migraine, etc.), congestive heart failure, angina pectoris, myocardial infarction, arrhythmia, hypertension, hyperglycemia, malignant tumors, and immunocompromised conditions;
- Alcohol abuse within 30 days prior to the study or alcohol/drug dependence within 6 months prior to the study; participation in any clinical trial within 30 days prior to baseline;
- Pregnant or breastfeeding women;
- Intellectual disability (IQ < 70).
Where it is running
- Shanghai Mental Health Center — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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