Reframing Endometrial Physiology by Advanced Integrated Research

Recruiting now

Conditions studied: Menorrhagia Due to Benign Causes

In brief

Heavy menstrual bleeding (HMB) affects 1 in 3 women and can significantly impact quality of life. Despite its prevalence, there is no accessible and accurate diagnostic test. This research will use wearable sensors, magnetic resonance imaging (MRI) scans, and biological sample collection to identify changes in the uterus linked with HMB. The investigators aim to recruit approximately 130 participants across two study sites over three years, including people with and without HMB.

Key facts

Study ID

NCT07557992

Run by

University Hospital Southampton NHS Foundation Trust

People needed

100

Starts

2026-02-06

Expected to finish

2030-02-01

Last updated by the study team

2026-04-30

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 18-45
• Having Periods

You may not qualify if…

• Currently pregnant or breastfeeding.
• Known uterine malignancy, severe anaemia requiring urgent treatment, or other acute gynaecological emergencies.
• Inability to undergo MRI (e.g., pacemaker, severe claustrophobia).
• Inability to provide informed consent.
• Current use of hormonal treatment, or use in the last 2 months

Where it is running

• University Hospital Southampton — Southampton, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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