Transcutaneous Auricular Vagus Nerve Stimulation Combined With Cervical Epidural Injection for Cervical Radiculopathy
Starting soon · Not applicable · Has a placebo group
Conditions studied: Cervical Radiculopathy, Cervical Spondylosis, Radicular Pain
In brief
This is a prospective, randomized, double-blinded, sham-controlled trial conducted to investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) combined with cervical epidural injection in the treatment of cervical radiculopathy. A total of 80 subjects will be enrolled and randomly assigned (1:1) to either the experimental group or the control group. The primary outcome measure is the proportion of subjects with a ≥50% reduction in the Numerical Rating Scale (NRS) pain score at discharge. Secondary outcomes include pain intensity, pain interference, psychological status, sleep quality, physical disability, and autonomic function measurements. Adverse events will be monitored throughout the study.
Key facts
- Study ID
- NCT07557823
- Run by
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- People needed
- 80
- Starts
- 2026-04-10
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-04-29
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18 and 85 years old.
- Body Mass Index (BMI) between 18 and 35 kg/m².
- American Society of Anesthesiologists (ASA) physical status I to III.
- Diagnosed with cervical radiculopathy, scheduled for selective cervical epidural injection.
- Estimated procedure duration ≤ 1 hour.
- Able to understand and provide written informed consent.
You may not qualify if…
- Arrhythmia requiring treatment, severe bradycardia, or postural orthostatic tachycardia syndrome.
- Neuromuscular disorders or auricular dermatitis.
- Cervical fracture, tumor, tuberculosis, or active infection confirmed by imaging.
- Contraindications to vagus nerve stimulation: carotid sinus hypersensitivity, bilateral carotid artery stenosis.
- Severe psychiatric disorder or history of substance abuse.
Where it is running
- The Second Affiliated Hospital, Zhejiang University School of Medicine Facility Address 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang Province, 310009, P.R.China — Hangzhou, Zhejiang, China
Full record on ClinicalTrials.gov
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