Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease

Recruiting now · Phase 1

Conditions studied: PARKINSON DISEASE (Disorder)

In brief

The purpose of this study is to find out whether a type of gentle nerve stimulation, called transcutaneous auricular Vagus Nerve Stimulation (taVNS), can help improve how the body regulates heart rate and blood pressure in people with Parkinson's Disease (PD). Problems with heart rate and blood pressure control are common and can make it harder for people to exercise or do daily activities. By using this non-invasive form of nerve stimulation and testing how it affects the body's natural responses, this study hopes to learn if taVNS could be a helpful tool to support physical therapy and improve overall function.

Key facts

Study ID

NCT07557706

Run by

University of Alabama at Birmingham

People needed

24

Starts

2025-09-15

Expected to finish

2026-12-31

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of idiopathic PD
• Stable medication for at least 4 weeks prior to the study

You may not qualify if…

• Use of beta blockers
• Sustained severe hypertension (>/= 180/110 mmHg while seated)
• Significant uncontrolled cardiac arrhythmia
• Unstable angina
• Congestive heart failure
• History of myocardial infarction
• History of seizures
• Severe cognitive impairment
• Pregnant women or women who are planning to become pregnant

Where it is running

• Wellness, Health and Research Facility at UAB — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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