Unified Protocol for Emotional Disorders: HiTOP-PRO Trial

Recruiting now · Not applicable

Conditions studied: Emotional Disorder

In brief

This randomised, parallel-group clinical trial evaluates the effects of the Unified Protocol (UP), a transdiagnostic cognitive-behavioural psychotherapy, on dimensional symptom outcomes aligned with the Hierarchical Taxonomy of Psychopathology (HiTOP) and on related temperamental/personality traits in adults with emotional disorders. Participants are randomly assigned (1:1:1) to UP, treatment as usual (TAU), or a waitlist (WL). Outcomes are assessed at baseline and after approximately 14 weeks. A planned follow-up assessment approximately 3 months after treatment completion is collected in the UP arm only.

Key facts

Study ID
NCT07557017
Run by
National Institute of Mental Health, Czech Republic
People needed
90
Starts
2025-10-08
Expected to finish
2028-07-31
Last updated by the study team
2026-04-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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