Patient Quality of Recovery After TAVR With Different Sedation Regimens
Recruiting now · Phase 4
Conditions studied: Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis
In brief
The goal of this clinical trial is to learn whether the type of sedation medication used during a transcatheter aortic valve replacement (TAVR) affects how people recover after the procedure. The main question this study aims to answer is whether different sedation regimens (propofol, dexmedetomidine, or midazolam with fentanyl) lead to differences in quality of recovery on the first day after the procedure. Researchers will compare three commonly used sedation medications (propofol, dexmedetomidine, or midazolam with fentanyl) to determine whether they lead to differences in recovery following a TAVR. Participants will: * Be enrolled before their scheduled TAVR procedure * Be randomly assigned to receive one of the three sedation medications during their procedure * Complete short surveys on postoperative days 1 and 7 about pain levels, how they feel during their recovery, and how satisfied they were with their anesthesia experience
Key facts
- Study ID
- NCT07556523
- Run by
- David Lyubashevsky
- People needed
- 126
- Starts
- 2026-03-16
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-04-29
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-90 years old, inclusive
- Undergoing transfemoral TAVR under Monitored Anesthesia Care (MAC)
- Speaks English or Spanish
- Consents to participate
You may not qualify if…
- Preoperative heart rate < 50 bpm or arrhythmias (e.g., AFib with RVR)
- Conduction abnormalities (e.g., 2nd/3rd degree AV block without pacer)
- Allergy or contraindication to study drugs
- Pulmonary artery pressure > 70mmHg
- Morbid obesity BMI > 50
- Pregnancy
- Unable to consent in English or Spanish
Where it is running
- Endeavor Health — Glenview, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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