Etiology and Prognostic Factors in Patients With Acute Liver Failure

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Conditions studied: Acute Liver Failure

In brief

Acute liver failure (ALF) is a rare but life-threatening condition with high mortality. Despite advances in supportive care and liver transplantation, prognosis varies significantly across etiologies, particularly in patients with indeterminate causes. This study aims to investigate the dynamic changes of clinical and biochemical indicators, identify potential etiologies-especially in indeterminate ALF-and evaluate prognostic risk factors. A dynamic prediction model will be developed to optimize clinical decision-making, including liver transplantation timing. Both retrospective and prospective cohorts will be included. Multi-omics analyses (including transcriptomics, proteomics, metabolomics, and metagenomic sequencing) will be performed on liver tissue and biological samples to explore disease mechanisms and etiology.

Key facts

Study ID: NCT07556055
Run by: Li-Ying Sun
People needed: 400
Starts: 2026-03-30
Expected to finish: 2037-12-31
Last updated by the study team: 2026-04-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients meeting diagnostic criteria for acute liver failure:
Adults: Acute onset without pre-existing liver disease, development of hepatic encephalopathy ≥ grade II within 4 weeks Pediatrics: Acute onset (<26 weeks), no chronic liver disease, coagulopathy not corrected by vitamin K: INR ≥1.5 with encephalopathy OR; INR >2 regardless of encephalopathy
Patients (or guardians) who provide informed consent

You may not qualify if…

Presence of end-stage extrahepatic disease without effective treatment
Pregnant or breastfeeding women
Inability or unwillingness to provide informed consent or comply with study procedures

Full record on ClinicalTrials.gov

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