Defining Retinal Structures Using Hyperspectral Retinal Imaging

Recruiting now · Not applicable

Conditions studied: Age-Related Macular Degeneration, Diabetic Retinopathy, Glaucoma, Retinal Diseases, Healthy Volunteers

In brief

This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease. Hyperspectral imaging captures retinal data across multiple wavelengths to generate detailed spectral information that may reveal features not visible with conventional retinal photography. Approximately 1000 participants will undergo multi-modal ophthalmic imaging in Melbourne, Australia, including hyperspectral imaging, OCT, fundus photography, and related tests. The study aims to compare hyperspectral imaging with standard imaging methods and assess its ability to identify retinal biomarkers associated with diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration.

Key facts

Study ID

NCT07555574

Run by

Center for Eye Research Australia

People needed

1000

Starts

2025-01-01

Expected to finish

2028-12-30

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18 years and older
• Able to provide informed consent
• Willing and able to attend a study visit at the Centre for Eye Research Australia
• Participants with diagnosed retinal or optic nerve disease (e.g., diabetic retinopathy, glaucoma, age-related macular degeneration)
• Age- and sex-matched healthy control participants without known retinal or optic nerve disease

You may not qualify if…

• Inability to provide informed consent
• Ocular conditions preventing adequate retinal imaging (e.g., dense cataract, severe corneal opacity, vitreous haemorrhage)
• Known contraindication to pharmacological pupil dilation
• History of narrow anterior chamber angle or risk of angle closure glaucoma where dilation is considered unsafe
• Any condition that, in the investigator's opinion, would compromise participant safety or image quality

Where it is running

• The Centre for Eye Research Australia — Melbourne, Victoria, Australia (enrolling)

Full record on ClinicalTrials.gov

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