Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis

Starting soon · Not applicable · Has a placebo group

Conditions studied: Multiple Sclerosis

In brief

The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life. The main questions this study aims to answer are the following: Does this treatment improve coordination and balance? Does it reduce fatigue and improve sleep and daily life? Does it change brain activity? Researchers will compare active brain stimulation to sham stimulation (a look-alike treatment that does not deliver real stimulation) to see if the treatment works. Participants will: Receive brain stimulation sessions for two weeks Attend assessment sessions before and after treatment Return for a follow-up visit after four weeks Complete tests of movement, fatigue, sleep, and thinking

Key facts

Study ID

NCT07555379

Run by

University of Sharjah

People needed

40

Starts

2026-09-01

Expected to finish

2028-06-01

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of Multiple Sclerosis according to the revised McDonald criteria
• Adult Age > 18 years
• Expanded Disability Status Scale (EDSS) score between 2.0 and 6.0
• Clinically stable disease status for at least 3 months prior to enrollment
• On stable disease-modifying therapy (DMT) for at least 3 months
• Ability to understand study procedures and provide informed consent
• Ability to ambulate independently or with assistive devices sufficient to complete motor assessments

You may not qualify if…

• Multiple sclerosis relapse within the past 3 months
• History of epilepsy or seizures
• Presence of implanted electronic devices (e.g., pacemaker, neurostimulator)
• Metallic implants in the head or skull incompatible with transcranial magnetic stimulation (TMS)
• Severe cognitive impairment preventing participation in assessments
• Pregnancy or planned pregnancy during the study period
• Other neurological or psychiatric disorders that may confound study outcomes
• Severe musculoskeletal or orthopedic conditions interfering with motor performance testing
• Contraindications to non-invasive brain stimulation or TMS

Where it is running

• University of Sharjah — Sharjah city, United Arab Emirates

Full record on ClinicalTrials.gov

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