TIS for NSSI in Adolescent Depression

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Temporal Interference Stimulation, Non Suicidal Self Injury, Major Depressive Disorder

In brief

Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain. This trial will compare the effectiveness of TIS to a placebo control on non-suicidal self injury (NSSI) in patients with major depressive disorder(MDD).

Key facts

Study ID

NCT07554755

Run by

The Second Hospital of Anhui Medical University

People needed

60

Starts

2026-04-30

Expected to finish

2027-01-31

Last updated by the study team

2026-04-28

Who can join

Age: 12 and older, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders 5th Edition) diagnostic criteria for major depressive disorder.
• Patients aged 12-22 years with at least one guardian to monitor them for 3 months
• HAMD-17 Total score ≥18
• Patients who had two or more non-suicidal self-injury behaviors meeting the 5.DSM-5 diagnostic criteria in the 2 weeks before admission (NSSI behavior of more than 5 days in the past year)
• Obtain informed consent from patients and guardians

You may not qualify if…

• Substance abusers such as psychoactive drugs or alcohol.
• Severe physical disability and unable to complete follow-up.
• Comorbid other major mental illnesses that meet the DSM-5 criteria, such as bipolar disorder, schizophrenia, mental retardation, dementia, severe cognitive impairment, attention deficit hyperactivity disorder, etc.
• Suffering from any severe physical disease, neurological disease, traumatic brain injury, etc, that affects the structure or function of the brain in the lifetime.
• Unable to read, understand and complete the assessment or to cooperate with the investigators.
• Any implants covering a pacemaker, metallic or magnetic objects in the body, or other conditions not suitable for TIS.
• Those who have received systematic psychotherapy (interpersonal relationship therapy, dynamic therapy, cognitive behavioral therapy) or TMS within 3 months before baseline.
• Other examination abnormalities considered to be inappropriate by investigators.

Where it is running

• The Second Affiliated Hospital of Anhui Medical University — Hefei, Anhui, China (enrolling)

Full record on ClinicalTrials.gov

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