Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty

Starting soon

Conditions studied: Knee Osteoarthritis, Rheumatoid Arthritis (RA)

In brief

This retrospective real-world study aims to compare the medium- and long-term clinical outcomes, safety, and economic benefits of different knee prosthesis brands used in primary unilateral total knee arthroplasty (TKA) at our hospital. The study will include adult patients who underwent first-time unilateral TKA between January 1, 2022 and December 31, 2025. Outcomes such as postoperative knee function, complications, length of hospital stay, quality of life, and medical costs will be evaluated. The results are expected to provide evidence to support prosthesis selection and optimize healthcare resource allocation.

Key facts

Study ID

NCT07553871

Run by

Second Affiliated Hospital of Wenzhou Medical University

People needed

3500

Starts

2026-05-31

Expected to finish

2030-12-01

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 18 years.
• Diagnosis of end-stage knee osteoarthritis, rheumatoid arthritis, or other conditions meeting the indication for TKA.
• First-time unilateral knee arthroplasty.
• Complete medical records, including perioperative records, prosthesis model records, detailed cost information, and regular postoperative follow-up records.

You may not qualify if…

• Revision knee arthroplasty, simultaneous bilateral arthroplasty, or concomitant arthroplasty of other joints.
• Arthroplasty performed for non-degenerative conditions such as tumour or acute trauma.
• Perioperative death or loss to follow-up.
• Severely incomplete clinical data that preclude valid analysis.

Full record on ClinicalTrials.gov

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