Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke)(Stroke-CORE)

Starting soon

Conditions studied: Intracerebral Haemorrhage, Paediatric Stroke, Stroke Acute, Stroke, Ischemic Stroke

In brief

The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital admission, through acute treatment, rehabilitation, and follow-up care, to the prevention of recurrent strokes. Strokes occurring in childhood are also included in this cohort study. In addition, the study seeks to establish effective structures for the early identification and inclusion of patients in clinical research (screening). In this context, structured screening processes are being implemented across all levels of care at participating sites within the Network University Medicine (NUM), a collaboration of German university hospitals. At the same time, the cohort serves as a platform within this network to systematically address open research questions in various areas of stroke care and to support the targeted planning and conduct of future clinical studies. The study includes patients with ischemic stroke (caused by a blocked blood vessel) or intracerebral hemorrhage (bleeding within the brain). Participation takes place in different thematic modules, each focusing on specific aspects of the disease course and its management. These modules address, among other topics, acute hospital treatment, measures to prevent recurrent strokes (secondary prevention), possible complications, pre-hospital care, rehabilitation, follow-up care, and long-term outcomes such as physical recovery, independence in daily life, and cognitive functions including memory and concentration. As part of the study, a range of data is collected. This includes sociodemographic information (such as age and living situation) as well as medical data, for example on prior conditions, diagnoses, treatments, and comorbidities. In addition, patients' health status is assessed at multiple time points in order to better understand the course of the disease. Depending on the level of participation, data collection may be complemented by the collection of biological samples, such as blood. These are obtained either during routine clinical procedures or through simple, minimally burdensome (non-invasive) methods. The study is structured into several levels that differ in the scope and depth of data collection. The basic level includes essential information, while higher levels involve more detailed assessments. In addition, some levels include the collection of biological samples, and there are optional supplementary modules in which patients may participate voluntarily. This tiered approach allows participation to be flexibly adapted to the individual situation while contributing to a nuanced and comprehensive understanding of stroke care.

Key facts

Study ID: NCT07553650
Run by: Charite University, Berlin, Germany
People needed: 12750
Starts: 2026-07-27
Expected to finish: 2030-06-30
Last updated by the study team: 2026-07-09

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of AIS or ICH; the AIS diagnosis may be diagnosed clinically or radiologically (i.e., focal neurological impairment of sudden onset, lasting more than 24 hours and of presumed vascular origin, or with proof of cerebral ischaemia corresponding to the clinical symptoms in neuroimaging); for ICH diagnosis requires clinical symptoms and radiological diagnosis of ICH
Hospital admission <24h after symptom onset
Age 18+ years for the basic Modules AIS and ICH; age <18 years for the basic Module paediatric stroke patients
Informed consent: Signed IC from patients capable of giving consent and understanding all content of the IC or IC of an appropriate patient representative or deferred consent, if patients are unable to consent themselves
Additional inclusion criteria are defined by the individual Modules

You may not qualify if…

In-hospital stroke
TIA
SAH
Stroke as a complication of a medical procedure
Enrolment in a randomised placebo-controlled interventional trial
Already enrolled in the SN STROKE base cohort

Where it is running

Universitätsklinikum Hamburg-Eppendorf (UKE) — Hamburg, Free and Hanseatic City of Hamburg, Germany
Charité University, Berlin, Germany — Berlin, State of Berlin, Germany
Universität Bielefeld, Universitätsklinikum OWL, Evangelisches Klinikum Bethel gGmbH, — Bielefeld, Germany
Universitätsklinikum Carl Gustav Carus Dresden — Dresden, Germany
Universitätsklinikum Erlangen — Erlangen, Germany
Universitätsklinikum Essen — Essen, Germany
Universitätsklinikum Heidelberg — Heidelberg, Germany
Universitätsklinikum Leipzig — Leipzig, Germany
Universitätsklinikum Schleswig-Holstein (UKSH), Campus Lübeck — Lübeck, Germany
Ludwig Maximilians Universität Klinikum — München, Germany
Universitätsklinikum Tübingen — Tübingen, Germany
Universitätsklinikum Würzburg — Würzburg, Germany

Full record on ClinicalTrials.gov

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