Utilization of 60-Day Peripheral Nerve Stimulation of the Occipital Nerves for the Treatment of Headache

Enrolling by invitation

Conditions studied: Headache

In brief

This prospective observational cohort study will evaluate clinical outcomes and health care resource utilization among adults who, independent of research participation, are clinically scheduled to undergo temporary 60-day occipital nerve peripheral nerve stimulation (PNS) as part of routine care for refractory headache disorders.

Key facts

Study ID

NCT07553533

Run by

Yale University

People needed

300

Starts

2026-05-01

Expected to finish

2028-05-01

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of a headache disorder for which the treating clinician has independently made the clinical decision to proceed with temporary 60-day occipital nerve PNS as part of routine care, including:
• Occipital neuralgia
• Chronic migraine
• Chronic tension-type headache
• Chronic cluster headache
• Cervicogenic headache
• Clinically scheduled to undergo temporary 60-day occipital PNS as part of routine care.
• Ability to provide informed consent.

You may not qualify if…

• Inability to provide informed consent.
• Coagulopathy that would prohibit PNS placement.
• Severe psychiatric illness interfering with participation.

Where it is running

• Yale — New Haven, Connecticut, United States
• Yale — Old Saybrook, Connecticut, United States

Full record on ClinicalTrials.gov

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