Effectiveness of 0.9% Normal Saline Soaking in Managing Acute Radiation Dermatitis

Starting soon · Not applicable

Conditions studied: Acute Radiation Dermatitis, Head and Neck Cancer (H&N), Sarcomas

In brief

The goal of this clinical trial is to learn if normal saline soaks can reduce the severity of acute radiation dermatitis in patients with sarcomas or head and neck cancer receiving radiotherapy. It will also learn if saline soaks can improve wound healing and reduce treatment interruptions caused by skin toxicity. The main questions it aims to answer are: 1. Does the application of normal saline soaks reduce the severity of acute radiation dermatitis according to CTCAE Version 5.0? 2. Does the use of normal saline soaks improve wound healing time and reduce the frequency and duration of radiotherapy interruptions? Researchers will compare standard care plus saline soaks (intervention group) to standard care alone (control group) to see if saline soaks reduce skin reaction severity and improve clinical outcomes. Participants will: 1. Be randomly assigned to receive either standard care alone or standard care with daily saline soaks 2. Apply saline-soaked gauze to the affected radiation area for 5-10 minutes once daily (intervention group only) 3. Attend weekly clinic visits for skin assessment during radiotherapy 4. Be assessed for skin reaction severity, wound healing, and treatment interruptions at baseline, after 4 weeks, and 2 weeks after completing treatment

Key facts

Study ID

NCT07553260

Run by

King Hussein Cancer Center

People needed

150

Starts

2026-05-01

Expected to finish

2027-06-01

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• Patients receiving definitive radiotherapy for sarcomas or head and neck cancer (primary or postoperative treatment)
• Planned radiation dose between 60-70 Gy according to disease-specific protocols
• No prior history of malignancy other than sarcomas
• Ability and willingness to comply with study procedures (>90% expected adherence)
• Signed informed consent

You may not qualify if…

• Patients receiving palliative radiotherapy
• Known pre-existing skin disorders affecting radiation area (e.g., systemic lupus erythematosus, scleroderma)
• ECOG performance status ≥2
• Previous radiotherapy to the same treatment field
• Any condition that, in the investigator's judgment, may interfere with participation or wound healing assessment

Where it is running

• King Hussien Cancer Center — Amman, Al-Jubeiha, Jordan

Full record on ClinicalTrials.gov

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