Muscle Imaging Project Using ANatomopathology and Full Field Optical Coherence Tomography

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Conditions studied: Myositis, Health Adult Subjects

In brief

Myositis is an inflammatory disease of the skeletal muscles that can be caused by infections, autoimmune diseases, or medications. Early diagnosis of these conditions is essential for optimal treatment. Anatomic pathology is the conventional method used to analyze muscle lesions, but it requires several weeks to obtain results. Full-field optical coherence tomography (OCT), a non-invasive imaging technique, could offer advantages in terms of speed and resolution for visualizing muscle inflammation. This research project compares histological pathology and full-field OCT for the analysis of muscle biopsies from healthy individuals and patients suspected of having myositis. The aim of this study is to establish an OCT reference standard by analyzing control muscle biopsies and then comparing muscle inflammation in confirmed cases of myositis. The advantages and limitations of both methods will also be evaluated.

Key facts

Study ID

NCT07552220

Run by

Centre Hospitalier de Mâcon

People needed

20

Starts

2026-04-01

Expected to finish

2028-12-01

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient > 18 years old ans has given his oral consent
• Patient who biospies are performed as part of care

You may not qualify if…

• Patient < 18 years old

Where it is running

• Centre Hospitalier de Mâcon — Mâcon, France

Full record on ClinicalTrials.gov

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