Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
Recruiting now
Conditions studied: Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
In brief
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients. Immunoparalysis will be assessed through monocyte HLA-DR expression and ex vivo lipopolysaccharide (LPS)-stimulated TNF-α production. The study will include three cohorts: elderly patients (≥65 years), younger adults (\<65 years), and healthy controls. The primary objective is to determine whether the presence, duration, intensity, and trend of immunoparalysis are associated with the incidence of VAP and other ICU-acquired infections. Secondary objectives include characterization of immunoparalysis dynamics, comparison of measurement methods, and evaluation of clinical outcomes.
Key facts
- Study ID
- NCT07551258
- Run by
- Hospital Universitari de Bellvitge
- People needed
- 170
- Starts
- 2026-05-01
- Expected to finish
- 2028-07-31
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- ≥18 years
- Mechanical ventilation expected >48h
- Intubation between 24h pre- and 48h post- ICU admission
- Informed consent
You may not qualify if…
- Known severe immunosuppression, including primary immunodeficiency disorders, advanced HIV infection (AIDS), active hematological malignancy under treatment, recent chemotherapy or immunosuppressive therapy
- High dose steroids at immunosuppressive doses
- Active autoimmune disease
- Pregnancy
- End-of-life situation
Where it is running
- Servei de medicina intensiva, Hospital Universitari de Bellvitge — L'Hospitalet de Llobregat, Barcelona, Spain (enrolling)
Full record on ClinicalTrials.gov
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