Role of Medical Thoracoscopy in Pleural Infection (PROMPT Trial)

Starting soon · Not applicable

Conditions studied: Pleural Infection, Pleural Infections, Pleural Infections and Inflammations

In brief

The PROMPT study is testing whether an early keyhole procedure called Medical Thoracoscopy, which lets doctors look inside the chest and remove infected fluid, works better than current standard treatment (medicines to break up thick fluid) for people with pleural infection. About 170 patients in several hospitals will be randomly assigned to one of the two treatments, and researchers will see which approach results in fewer additional procedures-such as another drain or surgery-within 30 days, as well as how quickly people recover and whether they experience any complications. Everyone in the study receives high-quality care, and the results will help doctors better understand which treatment gives patients the best chance of recovering quickly and safely

Key facts

Study ID

NCT07550530

Run by

Università Politecnica delle Marche

People needed

170

Starts

2026-11-01

Expected to finish

2029-03-31

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥ 18 years
• Clinical and radiological diagnosis of pleural infection (purulent, culture-positive, or pH < 7.2)
• Need of pleural drainage
• Able and willing to give informed consent

You may not qualify if…

• Chest drain in situ >24h before randomisation
• Post-traumatic pleural effusion
• Known allergy to fibrinolytic agents or contraindication to thoracoscopy
• Pregnancy or breastfeeding
• Life expectancy < 3 months from another illness
• Previous lung surgery (pneumonectomy) in the same side of pleural infection
• Previous pleurodesis in the same side of pleural infection
• Any contraindication to Medical thoracoscopy

Full record on ClinicalTrials.gov

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