Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

Starting soon

Conditions studied: Small Cell Lung Cancer, Head and Neck Cancer, Malignant Pleural Mesothelioma

In brief

This is an ancillary laboratory study to collect and bank blood and tissue samples. The biospecimens collected for this study will be invaluable for future research into predictive biomarkers and genomic alterations and their correlation with clinical outcomes.

Key facts

Study ID

NCT07550049

Run by

University of Kansas Medical Center

People needed

110

Starts

2026-04-01

Expected to finish

2029-04-01

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability of participant to understand this study, and participant willingness to sign a written informed consent. NOTE: Remote consenting allowed per IRB policy.
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Males and/or females age ≥ 18 years
• Diagnosis of one of the following:
• Advanced stage (IIIB to IV) non-small cell lung cancer (all types including mixed histology, without actionable mutations)
• Extensive-stage small cell lung cancer that are treatment naïve that will receive immunotherapy and chemotherapy
• Recurrent or metastaƟc squamous cell head and neck cancers, squamous cell, HPV posiƟve or HPV negaƟve, treatment naïve that will start immunotherapy and chemotherapy
• Malignant pleural mesothelioma that will be treated with immunotherapy and chemotherapy
• Eligible to receive chemotherapy (plaƟnum based) with an immune checkpoint inhibitor (single or double agents).
• Able to provide consent to obtain a blood sample, prior future genomic research of their samples.
• Planning to start therapy in the next 28 days.

You may not qualify if…

• Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements
• Presence of a condition(s) or diagnosis, either physical or psychological, or physical exam finding that precludes participation.
• Advanced stage (IIIB to IV) non-small cell lung cancer with actionable mutations
• Active viral infection (Hep C or B) requiring anti-viral therapy in the last 28 days. HIV patients on stable on anti-viral therapy able to receive therapy for the cancer are eligible to participate.
• Active use of prednisone equivalent to more than 10mg/day
• Second malignancy that requires systemic treatment at the time of consent

Full record on ClinicalTrials.gov

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