Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass
Starting soon
Conditions studied: Heparin Resistance, Cardiac Surgery, Cardiopulmonary Bypass
In brief
This study aims to investigate whether the level of antithrombin (AT) in the blood before cardiac surgery can predict how well patients respond to heparin, a medication used to prevent blood clotting during surgery with a heart-lung machine (cardiopulmonary bypass). Heparin requires antithrombin to work effectively. Some patients have lower levels of antithrombin, which may result in reduced response to heparin, a condition known as heparin resistance. This can lead to difficulties achieving adequate anticoagulation during surgery and may require additional medication or adjustments in treatment. In this study, an additional blood sample will be taken after anesthesia induction but before the administration of heparin. No changes will be made to the patient's treatment or care. Clinical data, including laboratory values, heparin dosing, and surgical outcomes, will be collected from routine medical records. The goal is to identify a clinically useful antithrombin threshold that can help detect patients at risk of heparin resistance. This may improve patient safety, optimize treatment strategies, and reduce unnecessary use of antithrombin therapy in the future.
Key facts
- Study ID
- NCT07549568
- Run by
- Sahlgrenska University Hospital
- People needed
- 300
- Starts
- 2026-06-01
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-05-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Planned cardiac surgery with cardiopulmonary bypass
- Ability to provide informed consent
You may not qualify if…
- Emergency cardiac surgery
- Ongoing antithrombin supplementation prior to surgery
- Known severe congenital coagulation disorder affecting interpretation of outcomes
- Severe liver failure
- Missing key data required to define heparin resistance (e.g., missing heparin dose or ACT values)
Where it is running
- Sahlgrenska University Hospital — Gothenburg, Västra Götalandsregionen, Sweden
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.