A Study of Cardiac Magnetic Resonance Imaging (CMR) for Evaluating Catheter-Associated Right Atrial Clot in People With Cancer

Recruiting now · Not applicable

Conditions studied: Adult Cancer Patients, Right Atrial Clot

In brief

The researchers are doing this study to see how well cardiac magnetic resonance imaging (CMR) scans can be used to examine the properties of central venous catheter-associated right atrial clot (RA clot). This could help doctors decide on the best treatment options.

Key facts

Study ID: NCT07549477
Run by: Memorial Sloan Kettering Cancer Center
People needed: 150
Starts: 2026-04-15
Expected to finish: 2029-04-01
Last updated by the study team: 2026-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Documentation of Disease
o Patients must have pathologically confirmed systemic cancer of any types and stages (solid tumors or hematologic malignancies) at the time of CMR which will be used to evaluate the presence or absence of cardiac mass and additional tissue characterization for confirmation of RATHR.
Definition of Disease [or Measurable Disease]
Cardiac mass (CMASS) will be initially localized on cine-CMR, on which it is defined via established criteria as a discrete tissue prominence independent from normal anatomic structures, quantified based on size (area, cross-sectional linear dimensions)
CMASS will be further categorized by type (CNEO or CTHR) based on CMR tissue characterization: CNEO and CTHR can be differentiated based on presence of contrast enhancement via the reference standard of LGE-CMR using established criteria previously validated by our group and others.
CTHR is defined as discrete mass(es) with avascular tissue properties (enhancement absent).
CTHR will be further subgrouped into RATHR after confirmation of its location and in relation to CVC.
CNEO is defined as discrete mass(es) with vascular tissue properties (enhancement present),
CNEO can be further sub-typed based on visually scored magnitude of enhancement (diffusely hyper-enhancing, mixed, predominantly hypo-enhancing) in accordance with established methods previously used by our group.
Required Organ Function:
o Adequate renal function defined as follows:
Creatinine clearance (CrCL) of ≥30 mL/min by the Cockcroft-Gault formula (Note: For agents for which renal excretion is not a major route of clearance and for which renal toxicity is not an issue, the threshold for creatinine clearance should be ≥30 mL/min.):
CrCl (mL/min) = [140 - age (years)] x weight (kg) 72 * creatinine (mg / dL)
Allergies
No history of allergic reaction to the gadolinium contrast agent or compounds of similar chemical or biologic composition
Subjects in RATHR+ group must meet the following criteria:
Adult cancer patients (stage I-IV) who are greater than 18 years of age
Presence of indwelling central venous catheter (Mediport, PICC, Hickman, pheresis cath, etc) with a minimal duration of 7 days prior to CMR
Presence of RATHR based on established CMR criteria (i.e. absence of enhancement on LGE-CMR)
Patients who underwent CMR within the past 3 months for evaluation of cardiac masses are eligible if confirmed for the presence of RATHR

You may not qualify if…

Known pre-existing CV disease which can affect hemodynamics within cardiac chambers as determined by the investigator, including
Arrhythmia - chronic persistent atrial arrhythmias
Cardiomyopathies including Ischemic or non-ischemic cardiomyopathy with LVEF <53%
Restrictive cardiomyopathy - cardiac amyloidosis, myocardial fibrosis
Constrictive pericarditis
Valvular heart disease with equal to or greater than moderate stenosis or regurgitation
Cardiac neoplastic involvement
Subjects will be excluded if they are unable to provide informed consent due to underlying clinical conditions and mental status.
Subjects will be excluded for getting CMR if they are
Subjects who would be normally excluded from undergoing a MRI examination as per institutional standard of care. At MSK, patients will be screened by radiology technicians using Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire (Appendix 1) prior to getting cardiac MRI
Subjects with presence of MRI incompatible metal fragments, aneurysm clip, implants or devices that would warrant avoidance of a strong magnetic field
Contraindications to receive gadolinium contrast
Renal dysfunction (GFR <30 mL/min) or end stage renal disease
Prior allergic reaction to gadolinium
Subject who are unable to tolerate CMR due to clinical status, respiratory compromise, or severe claustrophobia
Female participants who are pregnant or nursing
Subjects defined as vulnerable populations, as defined by 45 CFR 46
Participants at higher risk due to age, frailty, or the emergent nature of their condition

Where it is running

Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States (enrolling)
Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States (enrolling)
Memorial Sloan Kettering Bergen (Consent Only ) — Montvale, New Jersey, United States (enrolling)
Memorial Sloan Kettering Suffolk- Commack (Consent Only) — Commack, New York, United States (enrolling)
Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States (enrolling)
Memorial Sloan Kettering Cancer Center (All Protocol Activites) — New York, New York, United States (enrolling)
Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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