Comparative Evaluation of Preoperative Preparation Methods in Patients With Large Incisional Hernias

Recruiting now · Not applicable

Conditions studied: Incisional Hernia Repair, Ventral Hernia Repair

In brief

Patients with large, complex, or giant incisional hernias often require advanced preoperative optimization to facilitate safe abdominal wall reconstruction and reduce postoperative complications. Several strategies are currently used in clinical practice, including botulinum toxin A injection, progressive preoperative pneumoperitoneum, and their combination. However, the optimal differentiated approach based on hernia characteristics and abdominal wall tissue deficiency remains unclear. This study aims to compare the effectiveness and safety of different preoperative preparation strategies in patients with large postoperative ventral hernias and loss of abdominal wall domain. Outcomes of patients receiving botulinum toxin A, progressive preoperative pneumoperitoneum, combined preparation, or no specific preparation will be analyzed. The study will evaluate operative feasibility, ability to achieve fascial closure, postoperative complications, recurrence, and overall treatment outcomes.

Key facts

Study ID

NCT07549113

Run by

State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital

People needed

120

Starts

2024-04-01

Expected to finish

2028-05-01

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older
• Patients with ventral incisional hernia requiring elective surgical repair
• Large and/or complex hernia defects requiring preoperative preparation
• Ability to provide informed consent

You may not qualify if…

• Age under 18 years
• Emergency surgery
• Pregnancy
• Contraindications to botulinum toxin A injection or progressive pneumoperitoneum
• Severe uncontrolled comorbidities precluding surgery
• Inability or refusal to provide informed consent

Where it is running

• Ochapovsky Regional Clinical Hospital No.1 — Krasnodar, Krasnodarskiy Kray, Russia (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.