Cerebellar Transcranial Direct Current Stimulation in Parkinson's Disease

Enrolling by invitation · Not applicable

Conditions studied: PARKINSON DISEASE (Disorder)

In brief

Background \& Rationale: Treatment options for Parkinson's Disease (PD) often face challenges due to the variety of clinical subtypes, differing individual responses, and disease progression. Given its portability, affordability, safety, and ease of use, cerebellar transcranial direct current stimulation (ctDCS) presents as a promising option for home-based treatment with medical telemonitoring in the near future. Study Procedures: Participants are invited to complete questionnaires regarding quality of life, anxiety and depression, and symptoms related to their PD. On the first day, they will be assessed using the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III for motor impairment and the Cerebellar Cognitive Affective Syndrome scale (CCAS) for cognitive impairment. Participants will then undergo an additional 8 days of at-home cTDCS stimulation. On the 10th day, they will be reassessed using the MDS-UPDRS III and CCAS. One month later, they will complete again the questionnaires regarding quality of life, anxiety, depression, and symptoms related to their PD. Objective: Consequently, the primary goal is to investigate the effectiveness of ctDCS in addressing both motor and non-motor symptoms of PD

Key facts

Study ID

NCT07548801

Run by

Université Libre de Bruxelles

People needed

25

Starts

2025-09-24

Expected to finish

2026-11-01

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with mild to moderate PD MDS-UPDRS part 1III or between 1 and 3 on Hoehn and Yahr score
• Patients > 18 years of agE
• Patients who have signed written informed consent

You may not qualify if…

• Pregnant women
• Patients ≤ 18 years of age
• Presence of intracranial metallic hardware (e.g., vascular clips, orthopedic material)
• Presence of an implanted electronic device (e.g., pacemaker, cochlear implants, deep brain stimulator)
• History of epileptic seizures
• Active or past neurological condition affecting upper limb control (e.g., stroke, degenerative disease, tumor, traumatic sequelae), or any neuromuscular (e.g., upper limb polyneuropathy, myopathy) or orthopedic condition impairing upper limb motor control
• Subject unable to understand or perform the required motor tasks
• Psychotropic polypharmacy (regular use of neuroleptics, anti-epileptics, benzodiazepines, etc.)

Where it is running

• Hopital Erasme — Brussels, Belgium

Full record on ClinicalTrials.gov

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