Study of a Peptide Cream's Effect on the Facial Skin Barrier Using a Side-by-Side Comparison

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Skin Barrier Function, Skin Hydration, Topical Peptide Effects on Facial Skin Barrier Function

In brief

The goal of this clinical trial is to evaluate whether a topical face cream containing the peptide Acetyl Hexapeptide-37 improves skin hydration and strengthens the skin barrier compared to a placebo cream in healthy adult participants. The study uses a split-face design, in which one side of the face is treated with the peptide cream and the other side with a placebo (a cream without the active ingredient). The main questions it aims to answer are: * Does the peptide cream improve skin hydration and reduce transepidermal water loss compared to placebo? * Does the peptide cream affect skin erythema or cause irritation? * How do participants rate the comfort and tolerability of the peptide cream? Researchers will compare the treated and placebo sides of the face to assess differences in skin barrier function and tolerability. Participants will: * Attend a baseline visit for assessment of facial skin parameters, including hydration, transepidermal water loss, and erythema * Apply the peptide cream to one side of the face and the placebo cream to the other side once daily for 4 weeks * Attend weekly follow-up visits for non-invasive skin measurements * Record any skin sensations (e.g., stinging, tightness) or adverse effects throughout the study

Key facts

Study ID

NCT07548424

Run by

University of Split, School of Medicine

People needed

30

Starts

2026-05-04

Expected to finish

2027-01-01

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers who gave written informed consent

You may not qualify if…

• presence of active skin diseases or dermatological conditions
• known allergy or hypersensitivity to any ingredient of the study products
• pregnancy or breastfeeding
• use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines prior to or during the study

Where it is running

• University of Split School of Medicine — Split, Croatia (enrolling)

Full record on ClinicalTrials.gov

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