Effects of Intensive Glycemic Control in the Postoperative Period of Neurosurgical Patients on the Incidence of Surgical Site Infection

Starting soon · Not applicable

Conditions studied: Surgical Site Infection (SSI)

In brief

Surgical site infections (SSIs) are frequent complications in neurosurgical patients, often worsened by perioperative hyperglycemia. This randomized, controlled trial will compare intensive glycemic control (continuous insulin infusion, 140-180 mg/dL) with standard care (subcutaneous insulin, 81-180 mg/dL) in 544 patients. The primary outcome is SSI occurrence within 90 days post-surgery. Results aim to guide optimal glycemic management for SSI prevention in neurosurgery.

Key facts

Study ID

NCT07548112

Run by

University of Sao Paulo

People needed

572

Starts

2026-04-05

Expected to finish

2027-10-01

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged ≥18 years
• Patients undergoing elective cranial neurosurgical procedures classified as clean surgeries

You may not qualify if…

• Patients who underwent any surgical or neurosurgical procedure within 30 days prior to enrollment
• Presence of active infection at any site
• Patients undergoing emergency or urgent neurosurgical procedures
• Patients with trauma and exposed brain tissue
• Diagnosis of diabetic ketoacidosis
• Blood glucose levels >600 mg/dL

Full record on ClinicalTrials.gov

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