Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
Recruiting now · Not applicable
Conditions studied: Periodontitis, Smoking ( Cigarette)
In brief
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies. * The trial is a non-randomized comparative clinical study. * It includes 44 adult patients diagnosed with Stage II and III periodontitis. * The participants are divided into two equal groups: 22 current smokers and 22 non-smokers. * Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing. * A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection. * The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.
Key facts
- Study ID
- NCT07547202
- Run by
- Al-Mustansiriyah University
- People needed
- 44
- Starts
- 2026-01-01
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-04-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Systemically healthy.
- Diagnosed with Stage II and III periodontitis.
- Presence of ≥ 20 teeth (excluding third molars).
- Current smoker OR non-smoker
You may not qualify if…
- Presence of systemic diseases affecting the periodontium.
- Use of medications affecting inflammation.
- Received periodontal therapy in the past 6 months.
- Received antibiotic therapy in the last 3 months.
- Alcohol use.
Where it is running
- Al-Sadr Specialized Dental Center — Baghdad, Baghdad Governorate, Iraq (enrolling)
- Sadr Specialized Dental Center — Baghdad, Baghdad Governorate, Iraq (enrolling)
Full record on ClinicalTrials.gov
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