Choroidal Response to the Modified Defocus Incorporated Multiple Segments Spectacle Lenses

Starting soon · Not applicable

Conditions studied: Myopia

In brief

The goal of this study is to investigate the short-term changes in choroidal thickness and efficacy of the study spectacle lenses in children. Participants will be prescribed with a pair of study spectacle lenses for daily use and visit the clinic once every week for the first month for checkup and tests. After the first month of follow-up, participants will visit at 1 month, 6- and 12-month for checkup. Choroidal thickness, axial length and refractive errors will be monitored.

Key facts

Study ID

NCT07547072

Run by

The Hong Kong Polytechnic University

People needed

108

Starts

2026-04-25

Expected to finish

2028-02-29

Last updated by the study team

2026-04-23

Who can join

Age: 6 and older, up to 13. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Hong Kong Chinese
• Age at enrolment: 6 - 13 years
• Myopia in spherical power: -1.00D to -5.00D in both eyes
• Astigmatism: equal or less than 2.00D
• The sum of spherical power and astigmatism: equal or less than -7.00D
• Anisometropia (spherical equivalent refraction (SER)): equal or less than 1.50D
• Previous myopia progression (valid documentation dated within 2 years before screening):
• -0.50D (SER) per year or more in both eyes OR Axial length elongation: 0.27mm/year in both eyes
• If myopia is initially detected during screening, eligibility requires myopia (in SER) below the 3rd percentile curve of refraction in both eyes.12
• Best corrected visual acuity: LogMAR 0.04 or better in both eyes
• Ocular health: no abnormalities in both internal and external ocular health
• Binocular vision: no strabismus and other binocular abnormalities
• Normal colour vision
• Willing to wear the study spectacles all the time (10 hours per day, for 7 days per week)

You may not qualify if…

• Previous or current treatment for myopia control (e.g., red-light therapy, atropine, orthokeratology, specialized spectacle lenses and contact lenses and oral supplements for myopic control)
• Existing or past eye diseases or surgeries (e.g., strabismus surgery, amblyopia, oculomotor nerve palsies, corneal disease, intraocular disease, etc.) that may have an impact on vision or visual development
• Long-term medication (intake at least 3 days/week) or medication/supplements that affect eye health
• Systemic diseases that may have an impact on vision or visual development (e.g., endocrine, cardiac and respiratory diseases, diabetes, Down syndrome, etc.)
• Allergic to cyclopentolate eye drops
• Individuals who, in the judgment of the Investigator, are unable to cooperate and follow instructions during eye examination.

Full record on ClinicalTrials.gov

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