High-Frequency Repetitive Transcranial Magnetic Stimulation for Cognitive Improvement in Patients With Post-Stroke Cognitive Impairment

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Post-Stroke Cognitive Impairment (PSCI), Repetitive Transcranial Magnetic Stimulation (rTMS), Stroke

In brief

To clarify the clinical efficacy of high-frequency rTMS on patients with post-stroke cognitive impairment, fNIRS and EEG techniques were used to observe the changes in brain functional activities of patients with post-stroke cognitive impairment after rTMS treatment, and to clarify the neuroregulatory effect of rTMS on patients with post-stroke cognitive impairment.

Key facts

Study ID

NCT07546877

Run by

Qilu Hospital of Shandong University

People needed

40

Starts

2026-04-01

Expected to finish

2027-07-01

Last updated by the study team

2026-04-23

Who can join

Age: 35 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets the diagnostic criteria for stroke as stipulated in the "Guidelines for the Prevention and Treatment of Stroke in China (2021 Edition)", and the initial stroke diagnosis is confirmed by cranial CT or MRI examination, and is confirmed as the initial onset;
• The disease course is 1-12 months;
• Has cognitive impairment (MoCA < 26 points, education years ≤ 12 years, add 1 point to the score result);
• Age 35-75 years old, gender not limited;
• Stable vital signs, no progressive neurological symptoms;
• No severe aphasia, visual or auditory impairment, and able to complete the research protocol;
• Not using antidepressant drugs simultaneously;
• If using cognitive-improving drugs (such as donepezil, memantine), it should last for at least 3 weeks or more, and no dose adjustment will be made during the enrollment period;
• Voluntarily participate and sign the informed consent form.

You may not qualify if…

• Has a history of brain tumors, brain trauma, epilepsy or mental disorders;
• Had cognitive impairment before the stroke;
• Underwent craniotomy or had a skull defect;
• Had implanted metal or electronic devices (such as cardiac pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.);
• Has other serious diseases that may affect the study;
• Pregnant women

Where it is running

• Qilu Hospital of Shandong University — Jinan, China (enrolling)

Full record on ClinicalTrials.gov

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