Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery

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Conditions studied: Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia

In brief

This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.

Key facts

Study ID

NCT07545733

Run by

Harran University

People needed

60

Starts

2026-05-01

Expected to finish

2026-09-03

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged between 18 and 65 years
• American Society of Anesthesiologists (ASA) physical status I-II
• Scheduled for elective lumbar spine surgery in the prone position
• Planned general anesthesia with total intravenous anesthesia (TIVA)
• Ability to provide informed consent

You may not qualify if…

• Body mass index (BMI) ≥ 30 kg/m²
• History of significant pulmonary disease (e.g., COPD, asthma)
• Severe cardiovascular disease
• Pregnancy
• Known difficult airway
• Requirement for intraoperative vasopressor infusion due to hemodynamic instability
• Conversion to different surgical position or change in surgical plan
• Incomplete data or protocol deviation

Full record on ClinicalTrials.gov

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