Effects of Ultrasound-Guided Scalp Block on Opioid Use, Hemodynamics, and Postoperative Inflammation in Craniotomy

Starting soon

Conditions studied: Craniotomy Surgery

In brief

This study shows that in craniotomy patients using a skull pin head holder, an ultrasound-guided scalp block reduces perioperative opioid consumption, improves hemodynamic stability, and decreases the inflammatory response.

Key facts

Study ID

NCT07545655

Run by

Fatih Sultan Mehmet Training and Research Hospital

People needed

60

Starts

2026-04-10

Expected to finish

2027-03-10

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 years and older
• Scheduled for elective intracranial surgery with skull pin head holder fixation
• Classified as American Society of Anesthesiologists (ASA) physical status I-III
• Provided written informed consent in the preoperative period

You may not qualify if…

• Allergy to local anesthetics
• Coagulopathy or anticoagulant use
• Local infection at injection site
• Pregnancy or breastfeeding
• Chronic opioid use (>3 months) or chronic pain syndrome
• Severe psychiatric disorders affecting pain assessment
• Emergency surgery
• Active infection or rheumatic disease
• Hematological disease or malignancy (active or within 5 years)
• Recent use of biological agents, chemotherapy, or corticosteroids (within 30 days)
• NSAID use within 24 hours before surgery
• Advanced organ failure (NYHA III-IV, Child-Pugh C, eGFR <30 mL/min)
• Refusal to participate
• Communication difficulties preventing pain assessment

Where it is running

• Fatih Sultan Mehmet Training and Research Hospital — Istanbul, ataşehir, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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