Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus

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Conditions studied: Atherosclerosis

In brief

The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration).

Key facts

Study ID

NCT07545408

Run by

Assiut University

People needed

70

Starts

2026-06-01

Expected to finish

2027-08-01

Last updated by the study team

2026-04-22

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children and adolescents aged under 18 years diagnosed with JSLE according to the Systemic Lupus International Collaborating Clinics ( SLICC 2012 Criteria ).
• Disease duration of at least 6 months.
• Under regular follow-up at the study institution.

You may not qualify if…

• Patients with other autoimmune or connective tissue overlap diseases (e.g., mixed connective tissue disease, juvenile dermatomyositis).
• Patients with congenital heart disease or known structural cardiovascular abnormalities.
• Patients with chronic kidney disease stage 4 or 5.
• Patients currently receiving lipid-lowering therapy prior to enrolment

Full record on ClinicalTrials.gov

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