Effect of Positive End-Expiratory Pressure Titration on Venous Excess Ultrasound Score and Renal Outcomes in Patients With Acute Respiratory Distress Syndrome

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Conditions studied: Acute Respiratory Distress Syndrome (ARDS)

In brief

This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute Respiratory Distress Syndrome.

Key facts

Study ID

NCT07545252

Run by

Fayoum University

People needed

40

Starts

2026-04-12

Expected to finish

2026-10-12

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years.
• Diagnosis of ARDS according to the Berlin criteria.
• Invasive mechanical ventilation ≥24 hours.
• Requirement of PEEP ≥5 cmH₂O.

You may not qualify if…

• Known end-stage renal disease on chronic dialysis.
• History of renal transplantation.
• Pregnancy.
• Known severe tricuspid regurgitation.
• Chronic liver disease with portal hypertension.
• Poor ultrasound window precluding adequate venous Doppler assessment.

Full record on ClinicalTrials.gov

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