Music Therapy for Comatose Brain Injured Patients

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Conditions studied: Traumatic Brain Injury

In brief

The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to historic controls. Participants will listen to selected music through headphones. The investigators will compare cognitive function between groups at three time points: ICU discharge, hospital discharge, and three months after injury.

Key facts

Study ID

NCT07544602

Run by

Mercy Health Ohio

People needed

35

Starts

2026-04-07

Expected to finish

2028-04-07

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• blunt trauma
• computed tomography confirmed intracranial hemorrhage
• Glasgow Coma Scale (GCS) score 3-8 for 48+ hours postinjury
• mechanical ventilation
• age ≥18 years
• expected intensive care unit stay ≥72 hours
• approach family on hospital day 3 for consent; start study on hospital day 3 or 4 if consent given

You may not qualify if…

• GCS score >8 when considering candidacy
• imminent extubation without tracheostomy
• pregnancy or recent birth
• hospice care
• penetrating trauma
• bilateral fixed pupils
• cancer, advanced liver disease, end-stage renal disease, autoimmune disorder, prior brain disorder
• non-survivable injury
• other reasons in the opinion of the investigator or attending trauma physician

Where it is running

• St. Elizabeth Youngstown Hospital — Youngstown, Ohio, United States
• St. Elizabeth Youngstown Hospital — Youngstown, Ohio, United States

Full record on ClinicalTrials.gov

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