Autoimmune Hyperthyroidism in Prepubertal Children

Enrolling by invitation

Conditions studied: Autoimmune Hyperthyroidism, Children

In brief

The investigators propose a multicenter retrospective study to assess clinical, biochemical, and auxological characteristics at diagnosis and during follow-up in a cohort of Caucasian pediatric patients diagnosed with autoimmune hyperthyroidism before puberty. These prepubertal patients will be compared with a control group of post-pubertal patients with Graves' disease. This study aims to enhance the understanding of autoimmune hyperthyroidism in prepubertal patients by providing a detailed evaluation of disease onset, therapeutic response, and growth-related outcomes. The inclusion of a carefully matched post-pubertal control group will allow for robust comparative analysis and identification of age-dependent clinical patterns and prognostic indicators, ultimately supporting more tailored and effective management strategies in pediatric populations at this particular age.

Key facts

Study ID

NCT07544290

Run by

IRCCS Ospedale San Raffaele

People needed

100

Starts

2026-01-01

Expected to finish

2026-12-01

Last updated by the study team

2026-04-22

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with autoimmune hyperthyroidism

You may not qualify if…

• Subjects with hyperthyroidism not of autoimmune aetiology

Where it is running

• IRCCS Ospedale San Raffaele — Milan, Italy, Italy

Full record on ClinicalTrials.gov

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