Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
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Conditions studied: FFR-CT, CT Angiography, CT Perfusion, Coronary Arterial Disease (CAD)
In brief
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.
Key facts
- Study ID
- NCT07544277
- Run by
- IRCCS San Raffaele
- People needed
- 142
- Starts
- 2026-09-01
- Expected to finish
- 2029-09-01
- Last updated by the study team
- 2026-04-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient referred to our hospitals for elective CCTA for ruling out CAD
- CCTA evidence of moderate stenosis (50-69%) requiring functional assessment according to ESC guidelines
You may not qualify if…
- hemodynamically unstable conditions,
- previous revascularization,
- myocardial infarction,
- obesity (BMI>40 kg/m2),
- renal insufficiency (GFR<30 mL/min),
- atrial fibrillation or other significant arrhythmias; and
- other overt cardiovascular diseases affecting CTP performance (e.g., heart failure, severe valvular regurgitation),
- pregnancy and breastfeeding,
- contraindications to iodinated contrast agents or regadenoson.
Where it is running
- Azienda Ospedaliero-Universitaria Sant'Andrea — Roma, RM, Italy
- IRCCS Ospedale San Raffaele — Milan, Italy
Full record on ClinicalTrials.gov
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