The ISAR InflEx Trial (Inflammation and Exercise)

Recruiting now · Not applicable

Conditions studied: Inflammation, Obesity (Disorder)

In brief

A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.

Key facts

Study ID

NCT07543666

Run by

Department of Cardiology German Heart Center Munich TUM University Hospital

People needed

33

Starts

2026-01-01

Expected to finish

2027-06-01

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI 25.0 - 30.0 kg/m²
• age 18 - 45 years
• informed consent
• no regular physical activity (≤1x/week of structured exercise)
• willingness to strictly follow and adhere to the intervention protocol for the entire study

You may not qualify if…

• any acute or chronic illness
• pregnancy and breastfeeding
• active smoking
• Regular use of medication

Where it is running

• German Heart Centre — München, Bavaria, Germany (enrolling)

Full record on ClinicalTrials.gov

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