Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.
Starting soon · Not applicable
Conditions studied: Odontectomy (Tooth Extraction), Socket Preservation and Healing Following Simple, Non-surgical Extraction, Alveolar Bone Density and Postoperative Pain Management, Periapical Radiolucency
In brief
This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration. Participants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors: * Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction. * Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months. The goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.
Key facts
- Study ID
- NCT07542795
- Run by
- Cairo University
- People needed
- 10
- Starts
- 2026-09-28
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-04-21
Who can join
Age: 20 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Systemically healthy patients (ASA I or II)
- Age between 20 and 50 years
- Require simple, non-surgical extraction of a single tooth
- Presence of periapical radiolucency at the extraction site
- Willingness to comply with follow-up and provide signed informed consent
You may not qualify if…
- • Systemic diseases (e.g., uncontrolled diabetes, bone metabolic disorders)
- History of radiotherapy or chemotherapy
- Use of medications affecting bone metabolism (e.g., bisphosphonates, chronic steroids)
- Heavy smokers
- Pregnant or lactating women
- Poor oral hygiene or active acute infection/suppuration at the site
Where it is running
- Cairo University Faculty of Dentistry — Cairo, Egypt
Full record on ClinicalTrials.gov
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