Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment
Recruiting now
Conditions studied: Ectopic Pregnancy
In brief
The study "Doppler Flow in Tubal Ectopic Pregnancy as a Predictor of Treatment Success: Conservative and MTX Therapy" aims to evaluate the role of Doppler ultrasound parameters (RI, PI, and PSV) in predicting treatment success for tubal ectopic pregnancies. Ectopic pregnancies, affecting \~2% of all pregnancies (98% in fallopian tubes), pose significant risks, including rupture and maternal mortality. Diagnosis is typically achieved via transvaginal ultrasound, with Doppler imaging enhancing accuracy by detecting characteristic vascular patterns. Management options include conservative monitoring, methotrexate (MTX) therapy, or surgery, based on clinical stability, β-hCG levels, and ultrasound findings. While β-hCG levels are a known predictor of MTX treatment failure, there is no consensus on an optimal threshold. Prior research suggests increased vascularization on Doppler ultrasound may correlate with higher MTX success rates. This prospective study will involve 60 women aged 18-45 with stable, unruptured tubal ectopic pregnancies. It will assess Doppler parameters and other clinical factors as predictors of treatment success. Findings aim to address gaps in the literature and improve management strategies for tubal ectopic pregnancies.
Key facts
- Study ID
- NCT07541937
- Run by
- Meir Medical Center
- People needed
- 60
- Starts
- 2024-06-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-04-21
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Tubal ectopic pregnancy
- Hemodynamically stable, with no suspicion of rupture,
- Eligible for MTX or conservative therapy.
You may not qualify if…
- Intrauterine pregnancy
- Hemodynamic instability
- Suspected tubal rupture
- Other ectopic pregnancy: CSP, Ovarian, heterotopic pregnancy
Where it is running
- Meir Medical Center — Kfar Saba, Israel, Israel (enrolling)
Full record on ClinicalTrials.gov
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