The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients

Recruiting now

Conditions studied: Hypotension on Induction, Cardiac Surgery, Antihypertensive Agents, Anesthesia, Intravenous, Hemodynamics

In brief

This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.

Key facts

Study ID

NCT07541222

Run by

Konya City Hospital

People needed

160

Starts

2026-05-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-06

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 40 years and older
• Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)
• Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date
• Voluntary participation and signed informed consent

You may not qualify if…

• Emergency surgery
• Preoperative shock or requirement for high-dose inotropic/vasopressor therapy
• End-stage liver or kidney failure
• Uncontrolled hypertension
• Difficult intubation or prolonged induction process
• Ejection fraction less than 35%

Where it is running

• University of Health Sciences, Konya City Hospital — Konya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.