Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow

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Conditions studied: Intracranial Pressure, Ultrasonography

In brief

This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia. ONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization. Secondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.

Key facts

Study ID

NCT07540481

Run by

Kanuni Sultan Suleyman Training and Research Hospital

People needed

61

Starts

2026-04-15

Expected to finish

2027-03-16

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Patients undergoing surgery under general anesthesia
• Patients requiring internal jugular vein catheterization as part of routine clinical care
• Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography
• Provision of informed consent

You may not qualify if…

• Known intracranial pathology affecting intracranial pressure
• Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)
• Hemodynamic instability
• Contraindication to internal jugular vein catheterization
• Inability to obtain adequate ultrasound images

Where it is running

• University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital — Istanbul, Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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