Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study

Recruiting now

Conditions studied: Septic Shock, Multiorgan Failure, Sepsis

In brief

This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.

Key facts

Study ID

NCT07539883

Run by

Seoul National University Bundang Hospital

People needed

360

Starts

2026-01-22

Expected to finish

2026-12-31

Last updated by the study team

2026-04-20

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 19 years or older.
• Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025.
• Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI).

You may not qualify if…

• Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission.
• Patients with End-Stage Renal Disease (ESRD).
• Patients with missing critical covariates.

Where it is running

• Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea (enrolling)

Full record on ClinicalTrials.gov

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