Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery

Recruiting now

Conditions studied: Menstrual Cycle, Optic Nerve Sheath Diameter, Postoperative Nausea and Vomiting

In brief

This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery. Patients will be grouped according to menstrual cycle phase as follicular or luteal. ONSD measurements will be performed perioperatively, and postoperative nausea and vomiting as well as postoperative cognitive function will also be assessed. The study is designed to investigate whether hormonal variations during the menstrual cycle are associated with differences in intracranial pressure reflected by ONSD measurements and postoperative outcomes

Key facts

Study ID

NCT07539831

Run by

Konya City Hospital

People needed

110

Starts

2026-04-20

Expected to finish

2027-04-05

Last updated by the study team

2026-04-21

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged 18 to 45 years
• Scheduled for elective laparoscopic gynecologic surgery
• Menstrual cycle in the follicular phase or luteal phase
• American Society of Anesthesiologists (ASA) physical status I-II

You may not qualify if…

• Irregular menstrual cycle (e.g., polycystic ovary syndrome, early menopause, hypothalamic amenorrhea)
• Pregnancy or breastfeeding
• Neurological disease associated with intracranial pressure changes
• Glaucoma or another eye disease associated with high intraocular pressure
• Previous brain surgery
• Uncontrolled hypertension or severe cardiovascular disease

Where it is running

• Konya City Hospital — Konya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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