The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis

Recruiting now

Conditions studied: Primary Angle-Closure Glaucoma

In brief

Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.

Key facts

Study ID

NCT07539675

Run by

Zhongnan Hospital

People needed

150

Starts

2025-10-01

Expected to finish

2027-09-30

Last updated by the study team

2026-04-20

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically diagnosed with primary angle-closure glaucoma (PACG)
• Aged ≥ 50 years, no gender restriction
• Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
• Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
• Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery

You may not qualify if…

• Secondary glaucoma
• History of previous intraocular surgery
• Systemic diseases that can cause abnormal ocular zonules
• Other severe ocular diseases
• Long-term use of medications affecting connective tissue metabolism

Where it is running

• Zhongnan Hospital of Wuhan University — Wuhan, Hubei, China (enrolling)

Full record on ClinicalTrials.gov

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