Establishment of Biomarker Panel For Forecasting Chronic Graft-Versus-Host Disease (cGVHD) After Allo-HSCT
Starting soon · Not applicable
Conditions studied: Chronic Graft-Versus-Host Disease
In brief
This study is a single-center observational clinical study. Participants were enrolled as two cohorts of patients including discovery cohort and validation cohort. A total of consecutive 1000 patients receiving allo-HSCT in our center from 2021.01 to 2023.06 were retrospectively included as discovery cohort. A total of consecutive 500 recipients from 2023.06 to 2024.06 were retrospectively enrolled as validation cohort. Heparinized blood samples were collected prospectively at day +90 after HSCT and the onset of manifestations in patients with cGVHD or at matched time points in controls. Patients in the validation cohort also had samples drawn at approximately day +90. We used multiplex mass spectrometry with pooled plasma for biomarker discovery in comparing proteomic profiles between patients with and without chronic GVHD.
Key facts
- Study ID
- NCT07539220
- Run by
- Institute of Hematology & Blood Diseases Hospital, China
- People needed
- 1500
- Starts
- 2026-04-01
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-04-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with hematological disease survived more than 3 months after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Over 18 years old.
- Written informed consent or a waiver by the Ethics Committee (EC) at the site.
- HIV negative, HBV, HCV negative.
You may not qualify if…
- Previous autologous or allogeneic stem cell transplantation before enrollment.
- Suffering from mental illness or other conditions and not being able to cooperate with research treatment and monitoring requirements.
- Patients with other special conditions who were assessed as unqualified by the researchers.
Full record on ClinicalTrials.gov
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