Disclosing Agents as Photosensitizers in aPDT for Biofilm Control in Children

Starting soon · Not applicable

Conditions studied: Dental Plaque

In brief

This randomized controlled clinical trial aims to evaluate the effectiveness of plaque disclosing agents used as photosensitizers in antimicrobial photodynamic therapy (aPDT) for the control of dental biofilm in children aged 3 to 7 years. Participants will be allocated into groups to receive different treatment protocols, and biofilm levels will be assessed before and after the interventions. The primary outcome is the reduction of dental biofilm, aiming to determine whether disclosing agents can be an effective alternative photosensitizer in aPDT for pediatric patients.

Key facts

Study ID

NCT07539181

Run by

University of Nove de Julho

People needed

72

Starts

2026-05-31

Expected to finish

2026-08-30

Last updated by the study team

2026-04-20

Who can join

Age: 3 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children aged 3 to 7 years
• Both sexes
• Good general health status
• Classified as high caries risk according to the CAMBRA protocol (score ≥ +4 or presence of at least one disease indicator associated with two or more biological risk factors)
• Written informed consent obtained from a parent or legal guardian

You may not qualify if…

• Presence of systemic diseases
• Use of antibiotics within the last 30 days
• Use of antimicrobial mouthwash within 48 hours prior to sample collection
• Presence of structural dental alterations that may interfere with the standardization of the procedure
• Uncooperative behavior preventing safe clinical examination and intervention

Full record on ClinicalTrials.gov

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